abstract：OBJECTIVES:Tonsillectomy has recently been suggested as an effective treatment for PFAPA syndrome but little is known about its long-term efficacy. We compared the clinical features and the long-term outcome of a large cohort of patients with PFAPA syndrome treated with tonsillectomy or with standard medical treatment....

journal_title：Clinical and experimental rheumatology

authors： Vigo G,Martini G,Zoppi S,Vittadello F,Zulian F

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVES:One of the main goals of the European Autoimmunity Standardisation Initiative (EASI) is the harmonisation of test-algorithms for autoantibodies related to systemic autoimmune rheumatic diseases (SARD). METHODS:A questionnaire was used to gather information on methodology, interpretation, and the algorithm f...

journal_title：Clinical and experimental rheumatology

authors： Damoiseaux J,Agmon-Levin N,Van Blerk M,Chopyak V,Eriksson C,Heijnen I,Herold M,Høgåsen K,Musset L,Radice A,Rego de Sousa MJ,Viander M,Shoenfeld Y

更新日期：2014-07-01 00:00:00

abstract：:It is recognised that the genetic profiles that give rise to chronic inflammatory diseases, under the influence of environmental agents, might have been implicated in the host defence mechanism against lethal infections in the past. Behçet's disease (BD) is an immune-mediated inflammatory disease, expressed as vasculi...

journal_title：Clinical and experimental rheumatology

authors： Piga M,Mathieu A

更新日期：2014-07-01 00:00:00

abstract：:Primary central nervous system vasculitis (PCNSV) is an uncommon condition that affects the brain and the spinal cord. It is heterogeneous in presenting characteristics and outcomes. We report a patient with a catastrophic rapidly progressive course refractory to intensive treatment with pulses of methylprednisolone a...

journal_title：Clinical and experimental rheumatology

authors： Salvarani C,Brown RD Jr,Morris JM,Huston J 3rd,Hunder GG

更新日期：2014-05-01 00:00:00

abstract：:Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are closely related disorders that affect people of middle age and older, and frequently occur together. With the widespread use of newer vascular imaging modalities, large-vessel involvement (LVI) has increasingly been recognised in patients with GCA and les...

journal_title：Clinical and experimental rheumatology

authors： Muratore F,Pazzola G,Pipitone N,Boiardi L,Salvarani C

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:The present study was undertaken to investigate the association of peptidyl-arginine-deiminase type IV gene (PADI4) single nucleotide polymorphisms (SNPs) with rheumatoid arthritis (RA) susceptibility, and to determine whether there is any impact of PADI4 polymorphisms on RA subsets or phenotypes in a large ...

journal_title：Clinical and experimental rheumatology

authors： Du Y,Liu X,Guo JP,Liu X,Li R,Zhao Y,Liu X,Li MH,Li ZG

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:The ImmuKnow (Cylex) assay has been reported to predict the risk of infection in some diseases; however, it is uncertain whether ImmuKnow can predict the risk of infection in lupus nephritis (LN) patients receiving immunosuppressive therapy. METHODS:The ImmuKnow Immune Cell Function Assay (Cylex, Inc., Colu...

journal_title：Clinical and experimental rheumatology

authors： Liu J,Pan Y,Tang LJ,Bao JF,Hao J,Yu Q,Yuan WJ,Jin HM

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:The Systemic Lupus International Collaborating Clinics (SLICC) group has recently proposed a new set of criteria for the classification of systemic lupus erythematosus (SLE). We aimed to compare the sensitivity and specificity of the new SLICC criteria with those of the American College of Rheumatology (ACR)...

journal_title：Clinical and experimental rheumatology

authors： Sag E,Tartaglione A,Batu ED,Ravelli A,Khalil SM,Marks SD,Ozen S

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) constitute a subgroup of life-threatening diseases which affects the kidney in more than half of the patients at diagnosis. Currently, little has been published focusing on AAV patients with dialysis. We analysed AAV patients with chronic...

journal_title：Clinical and experimental rheumatology

authors： Chen YX,Zhang W,Chen XN,Ni LY,Shen PY,Wang WM,Chen N

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:Adjuvant-induced innate immune responses have been suspected to play a role in the initiation of certain autoimmune disorders. This study investigates the role of alum, an aluminum-based adjuvant in the induction of Sjögren's syndrome-like disorder in mice. METHODS:Inbred, female New Zealand Mixed (NZM) 275...

journal_title：Clinical and experimental rheumatology

authors： Bagavant H,Nandula SR,Kaplonek P,Rybakowska PD,Deshmukh US

更新日期：2014-03-01 00:00:00

abstract：:Systemic sclerosis remains a challenging disease despite progress that has taken place in the management of organ-based complications. Overall management strategies need to take into account the features of the disease that are common to almost all patients such as skin involvement, gastro-oesophageal manifestations a...

journal_title：Clinical and experimental rheumatology

authors： Nihtyanova SI,Ong VH,Denton CP

更新日期：2014-03-01 00:00:00

abstract：:Interstitial granulomatous dermatitis with arthritis (IGDA) is a rare idiopathic skin disorder with variable cutaneous expression, typically associated with a seronegative arthritis. Histopathology of this disorder reveals a granulomatous infiltrate with foci of collagen degeneration in the deep reticular dermis. We p...

journal_title：Clinical and experimental rheumatology

authors： Michailidou D,Voulgarelis M,Pikazis D

更新日期：2014-03-01 00:00:00

abstract：:The classification criteria recently developed by the Assessment of Spondyloarthritis International Society (ASAS) highlighted a specific entity: non radiographic axial spondyloarthritis (nr-axSpA). Although more and more widely used in the literature as well as clinical trials, limits and profile of this entity is st...

journal_title：Clinical and experimental rheumatology

authors： Fianyo E,Wendling D,Poulain C,Farrenq V,Claudepierre P

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to compare the cognitive function of antiphospholipid antibody (aPL)-negative systemic lupus erythematosus (SLE) and aPL-positive non-SLE patients. METHODS:Twenty aPL-negative SLE and 20 aPL-positive non-SLE female patients with no history of overt neuropsychiatric manifestations t...

journal_title：Clinical and experimental rheumatology

authors： Kozora E,Erkan D,Zhang L,Zimmerman R,Ramon G,Ulug AM,Lockshin MD

更新日期：2014-01-01 00:00:00

abstract：:Ultrasound (US) is a valuable imaging modality in the evaluation of joint and periarticular abnormalities in osteoarthritis (OA). It is able to image structural lesions as well as inflammatory changes in early and late disease. US is a relatively inexpensive, safe and quick-to-perform tool that can be used as a bedsid...

journal_title：Clinical and experimental rheumatology

authors： Iagnocco A

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:US and MRI play a significant role in the diagnosis of rheumatic diseases and in monitoring treatment response. This systematic review summarises and evaluates available evidence on the value of low-field MRI compared to US in rheumatic diseases. METHODS:A computerised literature search was conducted by a s...

journal_title：Clinical and experimental rheumatology

authors： Aleo E,Barbieri F,Sconfienza L,Zampogna G,Garlaschi G,Cimmino MA

更新日期：2014-01-01 00:00:00

abstract：:Ultrasonography in the '70s was a well-known and widely used method within several medical specialties but not in rheumatology. Initial development of the field was led by radiologists who mainly investigated the potential of ultrasound in the assessment of large joints. In the late '80s, the first studies supporting ...

journal_title：Clinical and experimental rheumatology

authors： Grassi W,Filippucci E

更新日期：2014-01-01 00:00:00

abstract：:Musculoskeletal ultrasound is an evolving technique widely used in rheumatology thanks to the numerous advances and the improved work on standardisation. This article deals with the new developments in terms of technology and validation. ...

journal_title：Clinical and experimental rheumatology

authors： D'Agostino MA,Terslev L

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:Limited data exist regarding the incidence rate and relative risks of major adverse cardiovascular events in women with lupus who have successfully delivered compared to those who have not been pregnant. METHODS:A retrospective, population-based matched cohort study was performed on women with lupus from 20...

journal_title：Clinical and experimental rheumatology

authors： Wu LS,Liu PH,Lin YS,Lin CP,Chang CJ,Chu PH

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to determine if routine clinical measures can predict the presence and severity of ultrasound synovitis in rheumatoid arthritis (RA) patients. METHODS:Bilateral 1-5 MCP (metacarpopharangeal) and wrist joints were examined using power Doppler (PD) ultrasound (US). Correlations b...

journal_title：Clinical and experimental rheumatology

authors： Nemoto T,Ogasawara M,Matsuki Y,Murayama G,Yamada Y,Sugisaki N,Ando S,Minowa K,Kon T,Tada K,Matsushita M,Yamaji K,Tamura N,Takasaki Y

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:Cryopyrin-associated periodic syndromes (CAPS) comprise a spectrum of distinct, rare, autosomal dominant autoinflammatory disorders of increasing severity caused by NLRP3 gene mutations. METHODS:We describe a 13-year-old female who presented, in the initial phase of the disease, recurrent episodes of high f...

journal_title：Clinical and experimental rheumatology

authors： Insalaco A,Prencipe G,Buonuomo PS,Ceccherini I,Bracaglia C,Pardeo M,Nicolai R,De Benedetti F

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:Coeliac disease (CD) is a chronic autoimmune disease of the small intestine caused by the ingestion of gluten, in which musculoskeletal manifestations may occur. Aim of this study was to evaluate the prevalence and severity of joint involvement in paediatric patients with CD using musculoskeletal ultrasound ...

journal_title：Clinical and experimental rheumatology

authors： Iagnocco A,Ceccarelli F,Mennini M,Rutigliano IM,Perricone C,Nenna R,Petrarca L,Mastrogiorgio G,Valesini G,Bonamico M

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:Various complaints of patients with fibromyalgia often resemble clinical features observed in patients with hypothalamic-pituitary diseases. The aim of this study was to evaluate whether patients with hypothalamic-pituitary diseases are at increased risk for fibromyalgia syndrome (FMS). METHODS:A questionna...

journal_title：Clinical and experimental rheumatology

authors： Harbeck B,Süfke S,Harten P,Haas CS,Lehnert H,Mönig H

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVES:To evaluate whether anti-TNF-α therapy (infliximab) administration alters circulating levels of ghrelin, an anti-inflammatory gastric peptide. We also assessed possible associations of circulating ghrelin concentrations with CRP and ESR levels, metabolic syndrome, demographic characteristics and other adipok...

journal_title：Clinical and experimental rheumatology

authors： Genre F,López-Mejías R,Miranda-Filloy JA,Carnero-López B,Gómez-Acebo I,Blanco R,Ochoa R,Rueda J,González-Juanatey C,Llorca J,González-Gay MÁ

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to evaluate the plasma levels of IL-17A in fibromyalgia patients, and to look for any correlations between this data and the concentrations of some pro- and anti-inflammatory cytokines. METHODS:We performed a study including 58 fibromyalgia patients and 39 healthy women matched for...

journal_title：Clinical and experimental rheumatology

authors： Pernambuco AP,Schetino LP,Alvim CC,Murad CM,Viana RS,Carvalho LS,Reis DÁ

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVES:Fibromyalgia (FM) is a form of non-articular rheumatism characterised by chronic widespread musculoskeletal aching. Although some works have investigated the possible role of oxidative stress in the pathophysiology of FM, none has analysed a significant number of oxidative markers in the same patients. Conse...

journal_title：Clinical and experimental rheumatology

authors： La Rubia M,Rus A,Molina F,Del Moral ML

更新日期：2013-11-01 00:00:00

abstract：:Pericarditis has several different causes, however, in about 70% of paediatric patients, a specific aetiology cannot be detected and the pericarditis is considered idiopathic. Recurrences may occur in up to 15-30% of cases. The pathogenesis of recurrent disease is controversial. Infectious, autoimmune and autoinflamma...

journal_title：Clinical and experimental rheumatology

authors： Gaspari S,Marsili M,Imazio M,Brucato A,Di Blasi Lo Cuccio C,Chiarelli F,Breda L

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:We aimed to identify different anti-TNF-α agents for ankylosing spondylitis (AS) assessed in randomised controlled trials (RCTs) and to compare them within a single evidence synthesis framework. METHODS:A Bayesian network analysis method was used to generate direct and indirect comparisons while maintaining...

journal_title：Clinical and experimental rheumatology

authors： Shu T,Chen GH,Rong L,Feng F,Yang B,Chen R,Wang J

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:Beyond their role in haemostasis, platelets can actively contribute to immunity. The activation of the platelet collagen receptor glycoprotein VI (GPVI) promotes the release of small extracellular vesicles called microparticles. These microparticles are found in the joint bathing fluid of patients with rheum...

journal_title：Clinical and experimental rheumatology

authors： Michou L,Cornélis F,Baron M,Bombardieri S,Balsa A,Westhovens R,Barrera P,Alves H,Radstake TR,Migliorini P,Bardin T,Petit-Teixeira E,Boilard E

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:IgG4-related Mikulicz's disease (IgG4-MD) has been recently established as a subtype of IgG4-related diseases involving the salivary and lacrimal glands, and the diseased glands are characteristically and highly responsive to corticosteroid therapy. We retrospectively evaluated ultrasonography (US) of the sa...

journal_title：Clinical and experimental rheumatology

authors： Takagi Y,Nakamura H,Origuchi T,Miyashita T,Kawakami A,Sumi M,Nakamura T

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:The aim of the present study is to investigate the demographics, aetiologies, complications, treatments and visual outcomes in paediatric uveitis patients in the French-speaking part of Switzerland. METHODS:Chart review of all patients diagnosed with uveitis before the age of 16 years, presenting to two ter...

journal_title：Clinical and experimental rheumatology

authors： Clarke LA,Guex-Crosier Y,Hofer M

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:In the 1-year, double-blind, placebo-controlled ATTEST trial, efficacy of abatacept or infliximab versus placebo was reported in patients with rheumatoid arthritis (RA) and an inadequate response to methotrexate (MTX). The current study estimated trial-based and real-life costs of abatacept and infliximab fo...

journal_title：Clinical and experimental rheumatology

authors： Benucci M,Stam WB,Gilloteau I,Sennfält K,Leclerc A,Maetzel A,Lucioni C

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:This paper aims to determine whether disease activity, systemic inflammation and metabolic syndrome are potential determinants of circulating leptin and visfatin levels in ankylosing spondylitis (AS) patients undergoing TNF-α antagonist therapy. We also assessed whether the infusion of infliximab may alter c...

journal_title：Clinical and experimental rheumatology

authors： Miranda-Filloy JA,López-Mejias R,Genre F,Carnero-López B,Ochoa R,Diaz de Terán T,González-Juanatey C,Blanco R,Llorca J,González-Gay MA

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:Treat-to-target strategies in the management of patients with rheumatoid arthritis (RA) involve intensifying medication as long as low disease activity or remission is not achieved. Our aim was to discuss reasons and opportunities for tapering and discontinuing medication when the target is achieved, in part...

journal_title：Clinical and experimental rheumatology

authors： Allaart CF,Lems WF,Huizinga TW

更新日期：2013-07-01 00:00:00

abstract：:Remission in psoriatic arthritis (PsA), albeit variably defined, is a desirable and achievable state, especially in the era of biologic therapy. Historically, studies have used remission criteria derived from rheumatoid arthritis (RA), which indicate that remission is seen in a greater percentage of patients than in R...

journal_title：Clinical and experimental rheumatology

authors： Mease P

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:Transverse myelitis (TM) is an uncommon neurologic condition characterised by the segmental involvement of the spinal cord. Although its etiology is unknown, a well established list of associations have been described, many items of which point towards an autoimmune and vasculitic process. TM is also a rare ...

journal_title：Clinical and experimental rheumatology

authors： Bitik B,Ucar M,Tezcan ME,Mercan R,Tufan A,Kocer B,Ozturk MA,Haznedaroglu S,Goker B

更新日期：2013-05-01 00:00:00

abstract：:Tumour necrosis factor-receptor associated periodic syndrome (TRAPS) is a rare autosomal dominant autoinflammatory disorder characterised by recurrent episodes of long-lasting fever and inflammation in different regions of the body, as musculo-skeletal system, skin, gastrointestinal tube, serosal membranes and eye. In...

journal_title：Clinical and experimental rheumatology

authors： Magnotti F,Vitale A,Rigante D,Lucherini OM,Cimaz R,Muscari I,Granados Afonso de Faria A,Frediani B,Galeazzi M,Cantarini L

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVES:The aim of this paper is to present two cases of severe idiopathic non-infectious paediatric panuveitis, unresponsive to traditional therapy, successfully treated with Adalimumab (HumiraTM, Abbott Pharmaceutical Inc.) in the long term. METHODS:The data of the two cases are presented and the literature is re...

journal_title：Clinical and experimental rheumatology

authors： Neri P,Eandi C,Arapi I,Posarelli C,Mariotti C,Giovannini A

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVES:The Behçet's Syndrome Activity Score (BSAS) is the first patient reported outcome measure developed to assess the global disease activity in patients with Behçet's syndrome (BS). We aimed to evaluate the reliability and validity of the Turkish version of BSAS for measuring disease activity in BS. We further ...

journal_title：Clinical and experimental rheumatology

authors： Yilmaz S,Simsek I,Cinar M,Erdem H,Kose O,Yazici Y,Pay S

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVES:Rheumatoid arthritis (RA) is associated with accelerated atherosclerosis and premature cardiovascular death. Anti-TNF therapy is thought to reduce clinical cardiovascular disease risk and improve vascular function in RA patients. However, the specific effects of TNF inhibitors on endothelial cell function ar...

journal_title：Clinical and experimental rheumatology

authors： Heathfield SK,Parker B,Zeef LA,Bruce IN,Alexander MY

更新日期：2013-03-01 00:00:00